Science

sEVs, sophisticated signal transducers

sEVs are highly sophisticated means of information exchange developed by nature over hundreds of millions of years. They are extremely efficient due to:

• their minute size, which enables them to circulate throughout the body
• their ideal size and composition, which contribute to their physical stability
• their fluid lipid envelope, which allows molecules anchored to it to move around
• the presence of thousands of cell receptor ligand proteins
• the curvature of their membrane, which perfectly exposes these proteins and,
• their cholesterol-rich membrane composition which mimics the lipid rafts of cells and favours the assembly of membrane proteins into interacting clusters.

They can be likened to non-living nano-cells that can circulate anywhere, with the unique purpose of interacting efficiently with cells, transmitting their message optimally, and then disappearing.

Ciloa’s Objectives and Achievements

Mastering the bespoke composition of these small extracellular vesicles (sEVs) should enable the selected information to be transmitted to the intended recipient.

Our 24 years of experience in research and industrialisation have allowed us to overcome many challenges of sEVs. We especially focused on making sure these sEVs can be customised and produced in a reliable way to obtain low-cost affordable drug candidates.